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PSYCHONEUROIMMUNOLOGY

The influence of psychological states on the immune system

Stress and Vaccines

An individual's immune response to vaccines can be diminished by both long and short-term psychological stressors, depression, and loneliness.

Adversity and Inflammation

Early childhood adversity is associated with higher inflammation.

Inflammation and Depression

Inflammation plays a role in inducing depression, with pro-inflammatory cytokines mediating the biological response to social and environmental stressors.

Inflammation and Mindfulness

Mind-body interventions including Tai Chi, yoga, and mindfulness augment anti-viral immune response and reverse inflammatory profiles.

Stress and the Hep B Vaccine

Stress and depression influence your ability to respond to the Hepatitis B vaccine and may shorten the protective antibody response.

Social Isolation and Ovarian Cancer

Compared to highly socially integrated women, those who are highly socially isolated, as well as those who are widowed, have an increased risk of developing ovarian cancer.

Therapy and Immune Dysregulation

Cognitive Behavior Therapy is an effective psychosocial intervention for normalizing immune system dysregulation.

Vitality and Heart Disease

Greater emotional vitality—characterized by a sense of energy, positive well-being, and effective emotion regulation—would be protective against coronary heart disease incidence.

Disposition and Vaccine Response

Psychological dispositions, including low self esteem, high negative affect, and high neuroticism, are associated with diminished immune response to vaccination.

Factors Affecting Chronic Inflammation

Chronic inflammation is affected by numerous factors including diet, sleep, exercise, infections, and psychological stress, and may be a common mechanism linking these factors with poorer lifespan health.

Acute Stress and Inflammation

Acute stress increases inflammatory markers.

Chronic Stress and Inflammation

Chronic stress upregulates inflammation.

Clinician Beliefs, the Placebo Effect, and Pain Relief

Whether a doctor believes they are prescribing a placebo or pain-relieving medication changes the amount of pain patients feel (even if the doctor uses the same language about the prescription).

Stress and the Common Cold

 Increases in psychological stress levels are associated with more frequent occurrences of the common cold.

Palliative Care and Cancer

Cancer patients who received early palliative care experienced less depression, fewer received agressive care, and these patients lived longer than those who did not.

Childhood Trauma and Increased Inflammation

Greater exposure to childhood maltreatment correlates with higher levels of inflammation in adulthood.

Conditioning, the Placebo Effect, and Allergies

Conditioning that associates a particular drink with a fake antihistamine reduces dust mite allergic reactions.

Stress and Infection Length

Experiencing stress can lead to longer periods of infection by hampering the immune system.

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